Blog
Ageing Associated with impairment of NO and Prostanoid dilator Pathways
The vascular endothelium has vasodilator, anti-thrombotic and athero-protective properties through the production of vasoactive mediators, such as nitric oxide (NO) and prostacyclin. NO is generated from the amino acid L-arginine by the enzyme NO synthase (NOS)....
Are We as Old as Our NO
Background-—Impaired generation and signaling of nitric oxide (NO) contribute substantially to cardiovascular (CV) risk (CVR) associated with hypertension, hyperlipidemia, and diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent...
NO and Geriatrics
The nation’s aging population is growing rapidly. By 2030, the number of adults age 65 and older will nearly double to 70 million. Americans are living longer and older adults can now live for many years with multiple chronic illnesses but with a substantial cost to...
Aging and Pulse Wave Velocity in Relation to NO
The Pulse Wave Velocity (PWV) is an important marker of arterial stiffness. Age related changes of arterial stiffness in relation to PWV and endothelial derived Nitric Oxide (NOx) are least explored. Aim and Objectives: The present study was aimed to assess a...
Associations of NO with Vitamin D in Adolescents
Nitric oxide (NOx) is an important biomolecule which interactswith othermolecules including 25(OH)D to mediate various metabolic pathways. Interactions and associations of NOx with 25(OH)D have been well studied both in vitro and in vivo, yet associations in...
Inhaled Nitric Oxide Applications in Pediatric Practice
The nitric oxide pathway plays a pivotal, yet diverse, role in human physiology, including modulation ofvascular tone, neural transmission and inflammation. Inhaled nitric oxide is a selective pulmonary vasodilator that has emerged rapidly as an important therapeutic...
Age Related Changes from Youth to Adult
Age related changes in brain cortex NO metabolism were investigated in mitochondria and cytosolic extracts from youth to adulthood. Decreases of 19%, 40% and 71% in NO production were observed in mitochondrial fractions from 3, 7, and 14 months old rats, respectively,...
NO Among Youth with Asthma
BACKGROUND: High fractional exhaled nitric oxide (FeNO) is an indicator of poor asthma control and has been proposed as a non-invasive assessment tool to guide asthma management. OBJECTIVE: We aimed to describe the prevalence of and factors associated with high FeNO...